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Abstract

Volume 3, Issue 4 (December 2001) 3, 305–309;

Vitamin E ameliorates aflatoxin-induced biochemical changes in the testis of mice

R.J. Verma, A. Nair

Department of Zoology, University School of Sciences, Gujarat University, Ahmedabad-380 009, India

Advance online publication 1 December 2001

Abstract

Aim: To assess the effect of aflatoxin on biochemical changes in the testis of mice and the possibility of amelioration by vitamin E treatment. Methods: Adult male albino mice were orally administered with 25 or 50 g of aflatoxin/animal/day (750 or 1500 g/kg body weight) for 45 days. The testis was isolated and processed for biochemical analysis. Results: There was a significant, dose-dependent reduction in DNA, RNA, protein, sialic acid contents and the activities of succinic dehydrogenase, adenosine triphosphatase and alkaline phosphatase in the testis of aflatoxin-treated mice as compared to the vehicle control. However, the acid phosphatase activity was significantly increased in the aflatoxin-treated mice. Vitamin E (2 mg/animal/day) treatment significantly ameliorated the aflatoxin-induced changes, except the acid and alkaline phosphataseactivities in the high dose group. Conclusion: Vitamin E treatment ameliorates the aflatoxin-induced changes in the testis of mice

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Asian Journal of Andrology CN 31-1795/R ISSN 1008-682X  Copyright © 2023  Shanghai Materia Medica, Chinese Academy of Sciences.  All rights reserved.