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Abstract

Volume 2, Issue 1 (March 2000) 2, 39–45;

Interference with the formation of the epididymal microenvironmenta new strategy for male contraception?

X.D. Gong, G.P.H. Leung, B.L.Y. Cheuk, P.Y.D. Wong

Department of Physiology, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong

Advance online publication 1 March 2000

Abstract

The cystic fibrosis transmembrane conductance regulator (CFTR) or the small conductance cAMP-activated chloride channel encoded by the CFTR gene has been shown to play an important role in the formation of the epididymal fluid microenvironment. Recent work in our laboratory has shown that this protein is also expressed by developing germ cells indicating a role of this protein in spermatogenesis. In view of the fact that the CFTR gene has a far reaching and widespread effeon human reproduction, understanding the role of CFTR in the male reproductive tissues and its intervention by pharmacological agents can open a new avenue of research into the development of novel male contraceptives.

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