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Volume 2, Issue 2 (June 2000) 2, 151–153;

Changes in soluble interleukin-2 receptor level in serum and Na+-K+-exchanging ATPase activity in semen of infertile men caused by antisperm antibody

J. Ni, Q.L. Li, W. Zhang, J.S. Xie, S.L. Bian

Department of Physiology, Harbin Medical University, Harbin 150086, China

Advance online publication 1 June 2000


Aim: To explore the possible mechanisms of male infertility caused by antisperm antibody (AsAb). Methods: The soluble interleukin-2 receptor (sIL-2R) level in serum was analyzed by ELISA and Na+-K+-exchanging ATPase activity in semen by phosphorus (Pi) assay. Results: The sIL-2R level in serum was significantly higher and the Na+-K+- exchanging ATPase activity in semen significantly lower in AsAb positive infertile men when compared with the controls. Conclusion: The AsAb titer varies with the sIL-2R level in serum. A decrease in Na+-K+-exchanging ATPase activity in semen may play a role in male infertility caused by AsAb.

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Asian Journal of Andrology CN 31-1795/R ISSN 1008-682X  Copyright © 2023  Shanghai Materia Medica, Chinese Academy of Sciences.  All rights reserved.