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Abstract

Volume 2, Issue 4 (December 2000) 2, 283–287;

Low dose gossypol for male contraception

Z.P. Gu, B.Y. Mao, Y.X. Wang, R.A. Zhang, Y.Z. Tan, Z.X. Chen, L. Cao, G.D. You, S.J. Segal

1.Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 200031, China
    2.Ren Ji Hospital, Shanghai Second Medical University, Shanghai 200001, China
    3.Zhong Shan Hospital, Medical Centre of Fudan University, Shanghai 200032, China
    4.Jing An District Central Hospital, Shanghai 200040, China
    5.Population Division, Rockefeller Foundation, New York, USA

Advance online publication 1 December 2000

Abstract

Aim: To ascertain whether the side effects of gossypol, hypokalemia and irreversibility, could be avoided on dose reduction. Methods: Seventy-seven male volunteers were divided into 3 groups: control (22 cases), 10 mg gossypol (29 cases) and 12.5 mg (26 cases). Serum levels of testosterone, FSH and LH were measured by RIA and potassium by flame photometry. Sperm counts and motility were examined before and regularly after treatment for the evaluation of contraceptive efficacy. Results: The average sperm density and motility started to decrease significantly by the end of month 2 of medication and gradually reached the infertility levels (<4 million /mL) in both treated groups. After that the 10 mg group was asked to take the same dose every other day for up to a total observation period of 16-18 months for the maintenance of infertility. Subjects in the 12.5 mg group did not take gossypol any more so as to observe the length of the loading dose required, but in a few, a maintenance dose of 12.5 mg every other day was instituted for a few more months. In both treated groups, none of the spouses was pregnant during the maintenance dose period. Serum levels of potassium, FSH, LH and testosterone were not significantly changed and not a single volunteer complained of myoasthenia. After cessation of drug administratioin, the semen data returned to pretreatment levels. Conclusion: A regimen with 10 or 12.5 mg of gossypol as the daily loading dose and 35 or 43.75 mg as the weekly maintenance dose could induce infertility in male volunteers without developing hypokalemia or irreversibility.

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Asian Journal of Andrology CN 31-1795/R ISSN 1008-682X  Copyright © 2023  Shanghai Materia Medica, Chinese Academy of Sciences.  All rights reserved.