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Abstract

Volume 2, Issue 4 (December 2000) 2, 293–296;

Cytogenetic and andrological status and ICSI-results in couples with severe male factor infertility

G. Haidl, B. Peschka, G. Schwanitz, M. Montag, K. van der Ven, H. van der Ven

Dept. of Dermatology and Andrology, 2Inst. of Human Genetics, 3Dept. of Gynecological Endocrinology and Reproductive Medicine, University of Bonn, 53105, Bonn, Germany

Advance online publication 1 December 2000

Abstract

Aim: To pursue whether cytogenetic aberrations correlate with specific spermatological or hormonal abnormalities. Methods: 305 infertile couples were investigated. All male partners were referred to a complete andrological work-up with physical examination, determination of hormones, HIV testing and semen analysis. Cytogenetic analysis was carried out in both partners by means of standard techniques using cultured lymphocytes from peripheral blood. Results: Among the 305 couples, 10 men (3.2%) and 10 women (3.2%) showed constitutional chromosomal aberrations, including reciprocal translocations (n=7), Robertsonian translocations (n=3), inversions (n=3), other structural aberrations (n=4) and sex chromosome aberrations (n=3). In addition to the impaired sperm count in most of the patients, a tendency to an increased proportion of spermatozoa with acrosome defect was observed. Conclusion: Chromosomal aberrations may contribute to the low fertilization and pregnancy rates in the infertile couples

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Asian Journal of Andrology CN 31-1795/R ISSN 1008-682X  Copyright © 2023  Shanghai Materia Medica, Chinese Academy of Sciences.  All rights reserved.