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Volume 1, Issue 1 (June 1999) 1, 67–72;
Urinary follicle stimulating hormone can be used as a biomarker to assess male reproductive function
X.R. Wang, J.W. Overstreet, H. Todd, Q. Qiu, J.H. Yang, S.Y. Wang, X.P.Xu, B.L. Lasley
1.School of Public Health, Nanjing Medical University, Nanjing 210029, China
2.Institute of Toxicology and Environmental Health, University of California, Davis, California 95616, USA
3.Anhui Meizhong Institute for Biomedical Science and Environmental Health, Anhui, China
4.School of Public Health, Harvard University, Boston, Massachusetts 02115, USA
Advance online publication 1 March 1999
| Abstract |
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Aim: To develop an algorithm for use in population-based studies to assess testicular function by measurements of total urinary follicle stimulating hormone (FSH). Methods: Total concentrations of urinary FSH were measured in a group of 44 men at the University of California, Davis (UCD) and were compared to FSH measurements in serum. On the basis of these and other published data, a urinary FSH value of >2 ng/mg creatinine (Cr) was selected as the cutoff point to identify men with elevated serum FSH (>12 IU/L) or low sperm counts (<20 million/mL). Results: The sensitivity and specificity of this algorithm for detecting elevated serum FSH in a group of 58 agricultural workers in the People's Republic of China were 100% and 50%, respectively. The sensitivity and specificity of this algorithm for detecting low sperm counts in a population of 105 infertility patients at UCD were 58% and 76%, respectively. Conclusion: This test may have particular value in identifying populations with no evidence of testicular toxicity, and in which labor-intensive semen studies may not be feasible.
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