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Abstract

Volume 17, Issue 5 (September 2015) 17, 811–814; doi: 10.4103/1008-682X.143751

Upgrading and upstaging of low risk prostate cancer among Korean patients: a multicenter study.

Insang Hwang1, Dong Hun Im2, Yung Bum Jung3, Seung Chol Park4, Jun Hwa Noh5, Dong Deuk Kwon1, Taek Won Kang1

1Department of Urology, Chonnam National University Medical School, Gwangju, Korea
2Department of Urology, Chosun University Medical School, Gwangju, Korea
3Department of Urology, Chonbuk National University Medical School, Junju, Korea
4Department of Urology, Wonkwang University School of Medicine, Iksan, Korea
5Department of Urology, Kwangju Christian Hospital, Gwangju, Korea, Korea

Correspondence: Dr. TW Kang (sydad@hanmail.net)

2014-12-30

Abstract

Only 54% of prostate cancer cases in Korea are localized compared with 82% of cases in the US. Furthermore, half of Korean patients are upgraded after radical prostatectomy (41.6%–50.6%). We investigated the risk factors for upgrading and/or upstaging of low‑risk prostate cancer after radical prostatectomy. We retrospectively reviewed the medical records of 1159 patients who underwent radical prostatectomy at five hospitals in Honam Province. Preoperative data on standard clinicopathological parameters were collected. The radical prostatectomy specimens were graded and staged and we defined a “worsening prognosis” as a Gleason score ≥ 7 or upstaging to ≥ pT3. Multivariate logistic regression models were used to assess factors associated with postoperative pathological upstaging. Among the 1159 patients, 324 were classified into the clinically low‑risk group, and 154 (47.5%) patients were either upgraded or upstaged. The multivariable analysis revealed that the preoperative serum prostate‑specific antigen level (odds ratio [OR], 1.131; 95% confidence interval [CI], 1.007–1.271; P = 0.037), percent positive biopsy core (OR: 1.018; 95% CI: 1.002–1.035;  0.032), and small prostate volume (≤30 ml) (OR: 2.280; 95% CI: 1.351–3.848;  0.002) were predictive of a worsening prognosis. Overall, 47.5% of patients with low‑risk disease were upstaged postoperatively. The current risk stratification criteria may be too relaxed for our study cohort.

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Asian Journal of Andrology CN 31-1795/R ISSN 1008-682X  Copyright © 2023  Shanghai Materia Medica, Chinese Academy of Sciences.  All rights reserved.