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Abstract

Volume 17, Issue 5 (September 2015) 17, 845–849; doi: 10.4103/1008-682X.146971

ICSI treatment of severe male infertility can achieve prospective embryo quality compared with IVF of fertile donor sperm on sibling oocytes

Ju‑Fen Zheng1,2, Xiao‑Bao Chen2, Lei‑Wen Zhao2, Min‑Zhi Gao2, Jie Peng1 , Xian‑Qin Qu1, Hui‑Juan Shi1, Xing‑Liang Jin1,3

1
China National Population and Family Planning Key Laboratory of Contraceptive Drugs and Devices, SIPPR, Shanghai, China; 2
Department of Reproductive Medicine,
Renji Hospital, Shanghai Jiao Tong University, Shanghai, China; 3
Sydney Centre for Regenerative and Developmental Medicine, Kolling Institute for Medical Research,
Sydney Medical School, University of Sydney, St. Leonards, NSW, Australia

Correspondence: : Dr. XL Jin (jinxingsz4@hotmail.com) and Dr. HJ Shi (shihuijuan2011@163.com)

2015-1-27

Abstract

Azoospermia, cryptozoospermia and necrospermia can markedly decrease the ability of males to achieve pregnancy in fertile females. However, patients with these severe conditions still have the option to be treated by intracytoplasmic sperm injection (ICSI) to become biological fathers. This study analyzed the fertilization ability and the developmental viabilities of the derived embryos after ICSI treatment of the sperm from these patients compared with in vitro fertilization (IVF) treatment of the proven-fertile donor sperm on sibling oocytes as a control. On the day of oocyte retrieval, the number of sperm suitable for ICSI collected from two ejaculates or testicular sperm extraction was lower than the oocytes, and therefore, excess sibling oocytes were treated by IVF with donor sperm. From 72 couples (73 cycles), 1117 metaphase II oocytes were divided into 512 for ICSI and 605 for IVF. Compared with the control, husbands' sperm produced a lower fertilization rate in nonobstructive azoospermia (65.4% vs 83.2%; P< 0.001), crytozoospermia (68.8% vs 75.5%; P< 0.05) and necrospermia (65.0% vs 85.2%; P< 0.05). The zygotes derived in nonobstructive azoospermia had a lower cleavage rate (96.4% vs 99.4%; P< 0.05), but the rate of resultant good-quality embryos was not different. Analysis of the rates of cleaved and good-quality embryos in crytozoospermia and necrospermia did not exhibit a significant difference from the control. In conclusion, although the sperm from severe male infertility reduced the fertilization ability, the derived embryos had potential developmental viabilities that might be predictive for the expected clinical outcomes.

Keywords: azoospermia; cryptozoospermia; embryonic development; fertilization; infertility; necrospermia; sibling oocytes

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Asian Journal of Andrology CN 31-1795/R ISSN 1008-682X  Copyright © 2023  Shanghai Materia Medica, Chinese Academy of Sciences.  All rights reserved.