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Management of non-obstructive azoospermia: advances, challenges, and expert recommendations
(Guest editors: Dr. Amarnath Rambhatla, Dr. Parviz Kavoussi, Dr. Rupin Shah, and Prof. Ashok Agarwal)
The advent of intracytoplasmic sperm injection (ICSI) has transformed male infertility treatment, offering solutions even for men with very low sperm counts or poor motility. However, in cases of non-obstructive azoospermia (NOA), where no sperm is present in the ejaculate due to testicular failure, the treatment depends entirely on the expertise of the andrologist to retrieve sperm, if any exist. NOA remains one of the most complex and challenging conditions in reproductive medicine.This special issue is dedicated to exploring the full spectrum of NOA, including its causes, diagnostic approaches, and current therapeutic options. Featuring expert and evidence based reviews, this special issue aims to provide practical and up-to-date guidance for clinicians working with these difficult cases and highlights strategies to support couples facing one of the most severe forms of male infertility.  |
| Editorial |
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| Male Fertility |
Management of non-obstructive azoospermia: advances, challenges, and expert recommendations
Rambhatla, Amarnath1,2; Kavoussi, Parviz K1,3; Shah, Rupin1,4; Agarwal, Ashok1,5
Asian J Androl 27: 277-278; 10.4103/aja202539
Full Text | PDF [74]
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| Review |
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Nonobstructive azoospermia: an etiologic review
Hubbard, Logan1; Rambhatla, Amarnath1; Glina, Sidney2
Asian J Androl 27: 279-287; 10.4103/aja202472
Abstract | Full Text | PDF [9]
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Anatomical considerations, testicular, and scrotal anatomy of nonobstructive azoospermia patients
Lin, Hao-Cheng1,2; Chen, Yan1,2; Fang, Yang-Yi1,2; Hong, Kai1,2
Asian J Androl 27: 288-292; 10.4103/aja2024102
Abstract | Full Text | PDF [8]
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| Sperm Biology |
Andrology laboratory technique for analysis of semen in men with azoospermia
Andrian Japari1,2, Dharani Moorthy2,3, Amarnath Rambhatla2,4
Asian J Androl 27: 293-297; 10.4103/aja202429
Full Text | PDF [9]
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| Male Fertility |
Differentiation between nonobstructive azoospermia and obstructive azoospermia: then and now
Hubbard, Logan1; Rambhatla, Amarnath1; Colpi, Giovanni M2
Asian J Androl 27: 298-306; 10.4103/aja202475
Abstract | Full Text | PDF [7]
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Diagnostic algorithm in men suspected with nonobstructive azoospermia
Bazzi, Mahdi1; Chabot, Matthew1; Rambhatla, Amarnath1; Chung, Eric2
Asian J Androl 27: 307-310; 10.4103/aja202529
Abstract | Full Text | PDF [7]
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Epigenetics of nonobstructive azoospermia
Gunes, Sezgin1; Metin Mahmutoglu, Asli2; Hekim, Neslihan1
Asian J Androl 27: 311-321; 10.4103/aja202463
Abstract | Full Text | PDF [9]
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Hypogonadotropic hypogonadism as a cause of NOA and its treatment
Salvio, Gianmaria1; Balercia, Giancarlo1; Kadioglu, Ates2
Asian J Androl 27: 322-329; 10.4103/aja202483
Abstract | Full Text | PDF [9]
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Clinician’s guide to the management of azoospermia induced by exogenous testosterone or anabolic–androgenic steroids
Al Hashimi, Manaf1,2,*; Pinggera, Germar-Michael1,3,*; Shah, Rupin1,4; Agarwal, Ashok1,5
Asian J Androl 27: 330-341; 10.4103/aja2024104
Abstract | Full Text | PDF [7]
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Medical treatment prior to micro-TESE
Dasgupta, Sujoy1,2; Le, Thanh Sang2,3; Rambhatla, Amarnath2,4; Shah, Rupin2,5; Agarwal, Ashok2
Asian J Androl 27: 342-354; 10.4103/aja202492
Abstract | Full Text | PDF [8]
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Varicocele and nonobstructive azoospermia
Kavoussi, Parviz K1; Gupta, Chirag2; Shah, Rupin3,4
Asian J Androl 27: 355-360; 10.4103/aja202444
Abstract | Full Text | PDF [9]
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| Opinion |
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Historical perspective of surgical sperm retrieval techniques for nonobstructive azoospermia
Shah, Rupin1,2,3; Rambhatla, Amarnath3,4; Kavoussi, Parviz K3,5
Asian J Androl 27: 361-364; 10.4103/aja202465
Full Text | PDF [82] PDF [82]
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| Review |
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Clinical predictors of successful outcomes for couples with nonobstructive azoospermic male partners undergoing micro-TESE
Kavoussi, Parviz K1; Gherabi, Nazim2; Saleh, Ramadan3,4
Asian J Androl 27: 365-369; 10.4103/aja202436
Abstract | Full Text | PDF [9]
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A review of testicular histopathology in nonobstructive azoospermia
Mostafa, Taymour1; Bocu, Kadir2; Malhotra, Vineet3
Asian J Androl 27: 370-374; 10.4103/aja202454
Abstract | Full Text | PDF [8]
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Technologies to improve sperm retrieval in men undergoing micro-TESE for NOA
Kavoussi, Parviz K1; Atmoko, Widi2; Pinggera, Germar-Michael3
Asian J Androl 27: 375-382; 10.4103/aja202450
Abstract | Full Text | PDF [8]
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Andrology laboratory techniques for micro-TESE/IVF/ICSI: a narrative review
Mantravadi, Krishna Chaitanya1; Anagnostopoulou, Christina2; Parikh, Firuza R3
Asian J Androl 27: 383-391; 10.4103/aja2024122
Abstract | Full Text | PDF [9]
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| Sperm Biology |
Sperm cryopreservation protocol for micro-TESE-retrieved sperm
Mangoli, Vijay1; Evgeni, Evangelini2; Wyns, Christine3
Asian J Androl 27: 392-398; 10.4103/aja202466
Abstract | Full Text | PDF [9]
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| Male Fertility |
Fresh versus frozen micro-TESE sperm and outcomes
Mantravadi, Krishna Chaitanya1,2; Martinez, Marlon2,3; Rahmat, Favian Ariiq2,4; Achmadsyah, Armand2,4; Savira, Missy2,4; Birowo, Ponco2,4
Asian J Androl 27: 399-408; 10.4103/aja202513
Abstract | Full Text | PDF [8]
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Second chance in fertility: a comprehensive narrative review of redo micro-TESE outcomes after initial failure
Elbardisi, Haitham1,2,3; Bakircioglu, Emre4; Liu, Wen5,6; Katz, Darren5,6,7
Asian J Androl 27: 409-415; 10.4103/aja202446
Abstract | Full Text | PDF [8]
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| Others |
Ex vivo microscopic testicular sperm extraction at the time of radical orchiectomy in men with nonobstructive azoospermia (NOA): a scoping review
Carlo Giulioni1,2, Nguyen Ho Vinh Phuoc2,3, Selahittin Cayan2,4
Asian J Androl 27: 416-422; 10.4103/aja202387
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| Male Fertility |
Microdissection testicular sperm extraction for men with nonobstructive azoospermia who have a testicular tumor in situ at the time of sperm retrieval
Lin, Hao-Cheng1,2; Tang, Wen-Hao1,2; Chen, Yan1,2; Fang, Yang-Yi1,2; Hong, Kai1,2
Asian J Androl 27: 423-427; 10.4103/aja2024109
Abstract | Full Text | PDF [8]
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Health risks associated with infertility and non-obstructive azoospermia
Huyghe, Eric1,2; Chiu, Peter Ka-Fung3
Asian J Androl 27: 428-432; 10.4103/aja20256
Abstract | Full Text | PDF [8]
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Future prospects for the advancement of treatment of men with NOA: focus on gene editing, artificial sperm, stem cells, and use of imaging
Akeem Babatunde Sikiru1, Manh Nguyen Truong2, Wael Zohdy3
Asian J Androl 27: 433-439; 10.4103/aja202486
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| Original Article |
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Association of higher serum follicle-stimulating hormone levels with successful microdissection testicular sperm extraction outcomes in nonobstructive azoospermic men with reduced testicular volumes
Song, Ming-Zhe1,*; Ye, Li-Jun1,2,3,*; Xiao, Wei-Qiang1; Huang, Wen-Si1,2,3; Wen, Wu-Biao1; Dai, Shun1; Lai, Li-Yun1; Peng, Yue-Qin1; Wu, Tong-Hua2,3,4; Sun, Qing5; Zeng, Yong2,3; Cai, Jing1
Asian J Androl 27: 440-446; 10.4103/aja202493
Abstract | Full Text | PDF [9]
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